%0 Journal Article
%A Reher, David
%A Klink, Barbara
%A Deutsch, Andreas
%A Voss-Böhme, Anja
%+ Genetic Diversity and Selection, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Max Planck Society
The Leipzig School of Human Origins (IMPRS), Max Planck Institute for Evolutionary Anthropology, Max Planck Society
%T Cell adhesion heterogeneity reinforces tumour cell dissemination: Novel insights from a mathematical model : 
%G eng
%U https://hdl.handle.net/11858/00-001M-0000-002D-D8BB-8
%R 10.1186/s13062-017-0188-z
%7 2017-08-11
%D 2017
%8 11.08.2017
%* Review method: peer-reviewed
%X Cancer cell invasion, dissemination, and metastasis have been linked to an epithelial-mesenchymal transition (EMT) of individual tumour cells. During EMT, adhesion molecules like E-cadherin are downregulated and the decrease of cell-cell adhesion allows tumour cells to dissociate from the primary tumour mass. This complex process depends on intracellular cues that are subject to genetic and epigenetic variability, as well as extrinsic cues from the local environment resulting in a spatial heterogeneity in the adhesive phenotype of individual tumour cells. Here, we use a novel mathematical model to study how adhesion heterogeneity, influenced by intrinsic and extrinsic factors, affects the dissemination of tumour cells from an epithelial cell population. The model is a multiscale cellular automaton that couples intracellular adhesion receptor regulation with cell-cell adhesion.
%K Cellular automaton, EMT, Intercellular adhesion, Mathematical model, Metastasis, Tumour heterogeneity, Tumour invasion
%J Biology Direct
%V 12
%] 18
%I BioMed Central
%@ 1745-6150